Infinitely rotatable sexless flanges simplify assembly, and the self centering provided by the centering ring lips help with alignment. It is necessary that components be separable axially to clear the centering ring lip when a flange is to be removed sideways. Flanges and seals are designed to be tightened to metal-to-metal contact. It is important that the clamps not be over tightened, or warping of the flanges could result. The clamp for use with ISO-FK flanges provides full clamping force while accommodating the tolerances of the components of a joint. It is fast and convenient in operation and is designed for repeated use. Applications include situations where flanges must be removed frequently, as in processing systems where components must be cleaned regularly, in the production evacuation of sealed-off tubes, or in leak testing.